Bronchiolitis Obliterans is the main reason for very poor survival rates after lung transplantation when compared to other solid organ transplantations. 5-year survival rates after solid organ transplantation are: Kidney 90%, Heart 80%, Liver 75% and Lung 50%. Patient registry data from the International Society of Heart and Lung Transplantation (ISHLT) are indicating Bronchiolitis Obliterans as the leading cause of death one year post lung transplantation.
There are more than 20 000 people today living with a lung transplant and approximately half of them will die in the next five years. There are currently no effective and approved drugs to treat Bronchiolitis Obliterans.